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Kurt G. Harris MD

PāNu means paleonutrition. The "paleo" here signifies "old" and not necessarily paleolithic. The PāNu approach to nutrition is grounded on clinical medicine and basic sciences disciplined by knowledge of evolutionary biology and paleoanthropology. The best evidence from multiple disciplines supports eating a pastoral (animal-based) diet rather than a grain-based agricultural one, while avoiding what I call the neolithic agents of disease - wheat, excess fructose and excess linoleic acid.

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PāNu Forum > High Uric acid levels, Doctor told me to cut out red meat!

Okay so I got my blood work done about 3 days into the diet (Maybe over three weeks ago now) so I could get a baseline. I just got the results back TODAY. My doctor called me in and told me that I had high uric acid levels.

URATE - 585 HI Reference Range: 230-480 umol/L
Alanine Transaminase (ALT) 51 HI Reference Range: 12-49

So I was bummed. So apparantely you avoid red meat because of the high purine levels in them. Here are some foods that are high in purine: Sardines, Asparagus, Bacon, Beef, Cauliflower, Chicken, Crab, Duck, Pork, Rabbit, Salmon, Spinach, Tripe, Tuna.

Jesus. That's most of my foods right there.... With the exception of eggs.... Even sardines which I've been shoving down my throat, nose pinched, these past few weeks is on the red list.

What am I supposed to do? What am I supposed to eat now?

Also, since this was taken a little while ago in the beginning of the diet I was still drinking some pop, and very laxed. I'm hoping this high uric acid is due to my high intake of fructose in the past, specifically of the HFCS variety. I have noticed that my eczema has started flaring up lately like crazy so maybe its a sign I'm developing gout.

February 9, 2011 | Unregistered CommenterAnonemouse

Dang! And it's not like you can find someone in the medical establishment who can interpret what's going on from a PaNu perspective, either. Have you considered contacting Chris Kresser (sp)? He is out in CA and works with integrative health from a "Paleo" perspective. He might have some insight for you.

February 9, 2011 | Unregistered CommenterPatricia C Psy.D.

So if you got those results after 3 days with the diet, do you really think its because of the diet? Or because of your old habits? What does your diet looks like right now? The dietary management of hyperuricemia includes reducing most foods high in purines. This is because you eat purines and your plasma levels rise. Yes, but excretion also rises. Insulin is a key element on uric acid clearance. Uric acid is also a marker of inflammation. You cant expect to fix your whole metabolism in less than a month...specially if you have a strong case of pathological IR.

February 9, 2011 | Unregistered CommenterKetotic

Patricia because of one of your comments in another thread I found the "Perfect Health Diet." I'm surprised you did not link it since they have their own take on uric acid and gout.:

"Zero-carb dieters are at risk for

Excess renal oxalate from failure to recycle vitamin C;
Excess renal uric acid from disposal of nitrogen products of gluconeogenesis and ketogenesis;
Salt and other electrolyte deficiencies from excretion of oxalate, urea and uric acid; and
Dehydration."

So I might just have to add one of the "clean starches" to my diet on a daily basis. Take out fructose all together.Limit red meat to maybe 25% of my protein intake. I'll see what effects these changes will have on my uric levels, and on my energy levels/weight.

Follow up question though. Anyone know what kind of effects ITERMITTENT FASTING has on uric acid? I am doing an 16/8 format at the moment where I will eat 50% of my nutritional requirements post work out. Now probably modified by eating 300-400 calories of white race to replenish my glycogen stores.

February 9, 2011 | Unregistered CommenterAnonemouse

Annlee THANKS for the links. I am slightly overweight atm. 20% BF, 184 pounds standing at 5, 10. My BMI shows that I am slightly overweight.

Since my ALT is high as well I reckon my liver is not working at optimal function. That added with the sudden uptake in red meat and fruits, and the VLC (50g about) I think are the causes, I'm overworking an unhealthy liver with ketosis and glyconeogenisis. I will add white rice to my diet, take out fruits completely and retest.

Ketotic: I agree with you and maybe I should wait till the retest before drawing some conclusions. However, since dr.harris recommends eating white rice, and the kind of intermittent fasting that I'm doing requires that you eat starchy carbs after your workout, and the fact that perfect health diet argues that uric acid level is affected by zero carb diets, I will go ahead and adjust my diet.

February 9, 2011 | Unregistered CommenterAnonemouse

You should wait and restest before reaching any conclusions or making any changes. 3 days into a diet is nowhere near enough time to say that the diet has anything to do with anything. I sincerely doubt 3 weeks of red meat intake is going to suddenly cause cause anything at all. Dietary problems take months and years to resolve and develop, not days and weeks.

While I don't disagree with the changes you propose, you do not have the information necessary to say that the changes you propose are going to have any effect compared to the way you've been eating for the past three weeks. For all you know, in the past three weeks, everything is magically better and your eczema flare is a total coincidence. Then you change your diet, retest, and the new test is a little better than the first test - but worse than you actually were before you made this random change halfway. If you actually want to know if the way you are eating now is making things better or worse, you have to keep eating that way up until the next test, THEN make changes.

If you are lifting heavily, you may experience pathological liver tests despite having perfectly normal liver function. This actually happened to me on a routine blood test: the doctor called me up and said I had significantly elevated AST and ALT. I said ok, scheduled another test in a few weeks, and didn't lift anything heavier than a fork for a week or two before I went. Perfect liver panel after that. Here's a study backing this idea: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291230/

So your conclusion that your liver is unhealthy may be wrong. Your high test results could easily be a product of your exercise regimen, and in any event 3 days on a paleo diet is not going to throw your liver into a pathological state

Anyway, the tl;dr version of all this is simple: you need to persist in a WOE for more than a few weeks before changing it if you want to have any idea if that WOE is actually working for you. If you keep making changes every three weeks every time you read something on the internet or get a test result from a month ago, you're never going to be able to determine what's actually work and what isn't.

February 10, 2011 | Unregistered Commenterpfw